Serra Mesa Vacations from $363

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Your Serra Mesa Vacation

Take the stress and hassle out of organizing your next escape with a Serra Mesa vacation package. Immerse yourself in the sights and sounds of this captivating neighborhood and experience everything it has to offer. Your trip to Serra Mesa wouldn't be complete without a visit to big-name attractions nearby such as Snapdragon Stadium, Fashion Valley Mall and Mission Valley Mall. No matter what your dream Serra Mesa vacation may look like, you can make it a reality with Expedia.

The Latest Serra Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Z

Hotel Z

3 out of 5
Downtown San Diego
Price was $589, price is now $363 per person
$363
per person
Jan 29 - Feb 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (1,212 reviews)

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was $1,184, price is now $618 per person
$618
per person
Feb 1 - Feb 6
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (2,743 reviews)
Such a wonderful trip to San Diego and the Sofia was lovely. Close to restaurants and venues and coming back to a clean comfy room was so nice. The view was also beautiful.

Reviewed on Nov 12, 2026

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was $1,038, price is now $644 per person
$644
per person
Feb 1 - Feb 6
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (1,585 reviews)

Pantai Inn

Pantai Inn

3.5 out of 5
Village of La Jolla
Price was $1,786, price is now $1,118 per person
$1,118
per person
Jan 8 - Jan 11
found 1 day ago
Roundtrip flight included
Minneapolis (MSP) to San Diego (SAN)
9.4/10 Exceptional! (1,002 reviews)

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
Mission Bay
Save 100% on your flight
Price was $1,371, price is now $900 per person
$900
per person
Feb 1 - Feb 6
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.8/10 Excellent! (2,946 reviews)

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

3 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Serra Mesa Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
8.4/10 Very Good! (6,373 reviews)
"Very nice!"

Reviewed on Nov 12, 2026

Wyndham San Diego Bayside
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$211 nightly
The price is $244 total per night from Nov 22 to Nov 23
$244 total
Nov 22 - Nov 23
Total with taxes and fees
9/10 Wonderful! (4,595 reviews)
"Loved everything about my stay. The staff all were friendly and the rooms were amazing!"

Reviewed on Nov 13, 2026

Hard Rock Hotel San Diego
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$82 nightly
The price is $94 total per night from Dec 13 to Dec 14
$94 total
Dec 13 - Dec 14
Total with taxes and fees
8.4/10 Very Good! (3,053 reviews)
"Great place. Clean and friendly staff"

Reviewed on Nov 11, 2026

Handlery Hotel
See all 9,227 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Stay near popular Serra Mesa attractions

Stadium Golf Center & Batting Cages

Enjoy a round of golf in San Diego at Stadium Golf Center & Batting Cages. Attend a sporting event or discover the beautiful sunsets in this walkable area.
See properties

Things to do

San Diego: 3 Hour Whale Watching Cruise

San Diego: 3 Hour Whale Watch Cruise with Legacy Whale Watch

$34
per adult
92% of travellers recommend
San Diego: 3 Hour Whale Watch Cruise with Legacy Whale Watch
San Diego: Luggage Storage in Marina

San Diego: Luggage Storage in Marina

$11
per adult
San Diego: Luggage Storage in Marina
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.